1705Non-Tuberculous Mycobacterial Bloodstream Infections in Patients with In-Dwelling Vascular Access Catheters- Role of Sickle Cell Disease

Background. Risk factors for non-tuberculous mycobacteria (NTM) lung infections have been well investigated. However, few studies have examined risk factors for NTM in-dwelling vascular catheter (IDVC) infections. Sickle cell anemia is known to affect several aspects of the immune system leading to relative immune deficiency. The purpose of this retrospective nested case-control study is to determine if sickle cell anemia (HbSS/SC) is a risk factor for NTM bloodstream infections among individuals with IDVCs. Methods. All NTM IDVC infections (cases) at Palmetto Health Richland Hospital from 2008-2014 were reviewed. Cases were matched 2:1 with controls who had IDVC infections due to organisms other than NTM. Infections due toMycobacterium avium complex and coagulase-negative Staphylococcus were excluded. Matching criteria included age within 10 years and IDVC infection within 3 months. Logistic regression was used to identify risk factors for IDVC infection due to NTM. Results. The 16 cases of NTM IDVC infection were matched to 32 controls with IDVC infections due to other organisms. Overall, the mean age of patients with IDVC infections was 48.5 years and 28 (58%) were male. Compared to the control group those with NTM infections were more likely to have sickle cell anemia 38% vs 6% (p = 0.006). Time from catheter placement to infection was similar for both groups; 199 vs 197 days for NTM and control groups respectively (p = 0.98). Most patients (68%) with NTM IDVC infections underwent catheter removal followed by antibiotics. Conclusion. IDVCs are a risk factor for NTM bloodstream infections. Sickle cell anemia appears to be a risk factor for IDVC infections due to NTM. This study is limited by the small sample size. A larger study is needed to further investigate the association between HbSS/SC and NTM IDVC infections. Disclosures. All authors: No reported disclosures.